Why the study?
Does losartan reduce 24-hour ambulatory blood pressure compared to placebo?
Does losartan reduce 24-hour ambulatory blood pressure compared to placebo?
Losartan provides effective 24-hour blood pressure reduction, which is further enhanced when combined with a low-dose diuretic.
Answers are grounded in this paper and cite their sources.
Supports losartan for sustained 24-hour BP control; confirms additive benefit with low-dose diuretics in hypertension.
Ambulatory blood pressure monitoring, which virtually eliminated antihypertensive placebo responses, demonstrated clear 24-hour efficacy for losartan, 50 mg once daily, as well as for higher doses of 100 mg once daily and 50 mg twice daily. This AT1 receptor blocker had antihypertensive effects that appeared additive when combined with low-dose diuretic therapy. Losartan was generally well tolerated.
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Michael A. Weber (1995) studied this question.
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