What question did this study set out to answer?

To evaluate the imaging efficiency, mass range, and lateral resolution of a bismuth cluster liquid metal ion source for biological time-of-flight secondary ion mass spectrometry (TOF-SIMS).

August 23, 2005Journal of the American Society for Mass SpectrometryOpen Access

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

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Authors

DTDavid TouboulCentre National de la Recherche Scientifique FKFelix KollmerUniversity of Münster ENE. NiehuisInfineon Technologies (Germany)

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Implication

Experimental imaging study reveals enhanced resolution and sensitivity in rat brain sections using bismuth cluster ion beams, indicating superior analytical performance over gold clusters.

Key Points

To evaluate the imaging efficiency, mass range, and lateral resolution of a bismuth cluster liquid metal ion source for biological time-of-flight secondary ion mass spectrometry (TOF-SIMS).
Fitted a bismuth liquid metal ion gun to a TOF-SIMS system to generate Bi(n)q+ cluster beams (n = 1–7, q = 1, 2).
Analyzed rat brain tissue sections across positive and negative secondary ion masses ranging from m/z 23 to >750 to quantify ion yields, disappearance cross sections, efficiencies, and lateral resolution.
Identified Bi3+ and Bi5(2+) as the most effective primary ion beams, achieving higher intensities and efficiencies than conventional Au3+ gold clusters.
Bi3+ produced a beam current at least five times greater than Au3+, optimizing large-area imaging, while Bi5(2+) enabled small-area imaging with high yields and useful lateral resolution under 400 nm.

Cite This Study

Touboul et al. (2005) studied this question.

synapsesocial.com/papers/69d736cff07a12db70b8a5ac https://doi.org/10.1016/j.jasms.2005.06.005

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Implication

Experimental imaging study reveals enhanced resolution and sensitivity in rat brain sections using bismuth cluster ion beams, indicating superior analytical performance over gold clusters.

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

Discussion

Member takes

Implication

Key Points

Cite This Study

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

Discussion

Member takes

Implication

Key Points

Cite This Study

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