Prospective multicenter pilot study demonstrates reduced plaque size and curvature in men with Peyronie's disease, suggesting early active-phase treatment is effective.
Intralesional treatment with hyaluronic acid can improve plaque size, penile curvature, and overall sexual satisfaction and seems preferably indicated in the early (active) phase of the disease. Furthermore, it is easy to perform and well tolerated.
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Zucchi et al. (2016) studied this question.