What question did this study set out to answer?

To develop and validate a rapid whole-blood glutathione assay and quantify normal baseline concentrations and biological variation across a large adult cohort.

January 1, 1996Clinical ChemistryOpen Access

Blood glutathione concentrations in a large-scale human study

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Authors

JRJohn P. RichiePennsylvania State University LSLukasz SkowronskiBydgoszcz University of Science and Technology PAPaul AbrahamUniversité Claude Bernard Lyon 1

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Implication

Cross-sectional analysis reveals threefold variability in blood glutathione levels across 715 adults, indicating significant modulation by smoking status and age-related sex factors.

Key Points

To develop and validate a rapid whole-blood glutathione assay and quantify normal baseline concentrations and biological variation across a large adult cohort.
Validated an analytical assay demonstrating a detection limit under 5 pmol, an interassay variation of 2.3%, and a sampling variation of 3.6%.
Screened whole blood glutathione (GSH) concentrations in a cohort of 715 free-living adults.
Whole blood GSH concentrations showed a threefold range with an overall mean of 1.02 mmol/L and a coefficient of variation of 17%.
GSH concentrations were 8% to 10% higher in smokers than in nonsmokers (P < 0.001).
Although absolute GSH did not differ by sex, GSH/hemoglobin ratios were 8% to 18% greater in women younger than 55 years compared with older individuals (P < 0.05).

Cite This Study

Richie et al. (1996) studied this question.

synapsesocial.com/papers/69d738843f2a6ac123b8a9ad https://doi.org/10.1093/clinchem/42.1.64

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Implication

Cross-sectional analysis reveals threefold variability in blood glutathione levels across 715 adults, indicating significant modulation by smoking status and age-related sex factors.

Blood glutathione concentrations in a large-scale human study

Discussion

Member takes

Implication

Key Points

Cite This Study

Blood glutathione concentrations in a large-scale human study

Discussion

Member takes

Implication

Key Points

Cite This Study

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