Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.
Why the study?
Does familial hypercholesterolemia impair endothelium-dependent dilation in children?
Population
60 children, including 30 with familial hypercholesterolemia aged 7-17 years, and 30 healthy age- and…
Comparison
Familial hypercholesterolemia vs Healthy age- and sex-matched controls
Design
Case-control
Authors
Discussion
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Implication
Supports early endothelial dysfunction in familial hypercholesterolemia; hypothesis-generating for lipoprotein(a) as pediatric target.
Structured PICO
Does familial hypercholesterolemia impair endothelium-dependent dilation in children?
P
Population
60 children, including 30 with familial hypercholesterolemia (2 homozygotes, 28 heterozygotes, total cholesterol 240-696 mg/dl) aged 7-17 years (median 11), and 30 healthy age- and sex-matched controls.
I
Intervention
Familial hypercholesterolemia (observational exposure)
C
Comparator
Healthy age- and sex-matched controls
O
Outcome
Endothelial function assessed by flow-mediated dilation (endothelium-dependent dilation) of the superficial femoral artery using high-resolution ultrasound in response to reactive hyperemiasurrogate
Children with familial hypercholesterolemia exhibit early impairment of endothelium-dependent dilation, which correlates with elevated lipoprotein(a) levels.
Cite This Study
Sørensen et al. (1994) studied this question.