August 30, 2017New England Journal of Medicine
Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung Cancer
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Discussion
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Implication
Review reports advances in molecular characterization and targeted immunotherapies for advanced non-small-cell lung cancer, indicating progress toward personalized clinical oncology.
Key Points
- Summarize recent advances in diagnostic and therapeutic approaches for advanced non–small-cell lung cancer, focusing on molecular profiling to guide targeted therapies and immunotherapy.
- Narrative review synthesizing recent clinical and translational literature on advanced non–small-cell lung cancer.
- Evaluation of molecular characterization methodologies used to determine therapeutic response to targeted agents and immune checkpoint inhibitors.
- Molecular characterization reliably predicts patient-specific tumor responsiveness to targeted therapies and immunotherapies.
- Integrating precision diagnostic profiling into clinical workflows optimizes individualized systemic treatment selection alongside population-level smoking cessation gains.
Cite This Study
Reck et al. (2017) studied this question.