What question did this study set out to answer?

Determine whether intrauterine exposure to mild analgesics alters male reproductive development and increases cryptorchidism risk.

November 8, 2010Human ReproductionOpen Access

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

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Authors

DKDavid M. KristensenRoskilde University UHUlla HassTechnical University of Denmark LLLaurianne LesnéInserm

Discussion

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Implication

Combined human and animal study reveals increased cryptorchidism risk after prenatal mild analgesic exposure, suggesting anti-androgenic disruption of masculinization.

Key Points

Determine whether intrauterine exposure to mild analgesics alters male reproductive development and increases cryptorchidism risk.
Evaluated the association between timing and duration of mild analgesic use during pregnancy and cryptorchidism risk in human offspring.
Assessed anti-androgenic effects and masculinization markers in rat models following in utero analgesic exposure.
Longer duration and specific timing of maternal mild analgesic use were associated with an increased risk of cryptorchidism.
In utero exposure caused anti-androgenic effects in rats, resulting in impaired male fetal masculinization.

Cite This Study

Kristensen et al. (2010) studied this question.

synapsesocial.com/papers/69d73d528e958094d1b8a6b6 https://doi.org/10.1093/humrep/deq323

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November 8, 2010Human ReproductionOpen Access

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

View Full Paper

Ask AI

Bookmark

Authors

DKDavid M. KristensenRoskilde University UHUlla HassTechnical University of Denmark LLLaurianne LesnéInserm

Discussion

Member takes

Implication

Combined human and animal study reveals increased cryptorchidism risk after prenatal mild analgesic exposure, suggesting anti-androgenic disruption of masculinization.

Key Points

Determine whether intrauterine exposure to mild analgesics alters male reproductive development and increases cryptorchidism risk.
Evaluated the association between timing and duration of mild analgesic use during pregnancy and cryptorchidism risk in human offspring.
Assessed anti-androgenic effects and masculinization markers in rat models following in utero analgesic exposure.
Longer duration and specific timing of maternal mild analgesic use were associated with an increased risk of cryptorchidism.
In utero exposure caused anti-androgenic effects in rats, resulting in impaired male fetal masculinization.

Cite This Study

Kristensen et al. (2010) studied this question.

synapsesocial.com/papers/69d73d528e958094d1b8a6b6 https://doi.org/10.1093/humrep/deq323

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