SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Yue Li; Xinhua Yang; Weijie Zhu; Yuxia Xu; Jiangjun Ma; Caiyun He; Fang Wang

doi:10.1186/s12935-022-02757-x

November 12, 2022SHILAP Revista de lepidopterologíaOpen Access

SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

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Key Points

To evaluate the associations between SWI/SNF complex gene alterations, tumor mutational burden, microsatellite instability, and immunotherapy outcomes across diverse cancer types.
Analyzed next-generation sequencing data from 4,591 pan-cancer cases.
Evaluated high tumor mutational burden (TMB-H) and high microsatellite instability (MSI-H) across cohorts including colorectal, gastric, and non-small cell lung cancers.
Assessed clinical response rates following treatment with immune checkpoint inhibitors (ICIs).
SWI/SNF complex gene mutations occurred frequently and demonstrated strong positive associations with both TMB-H and MSI-H status across multiple cancer types.
Patients harboring SWI/SNF complex alterations achieved superior therapeutic responses to immune checkpoint inhibitor treatments compared to those with wild-type genes.

Implication

Pan-cancer genomic analysis reveals SWI/SNF mutations correlate with higher tumor mutational burden and improved immunotherapy response across cancers, highlighting their predictive biomarker value.

Abstract

SWI/SNF complex genes are frequently mutated and are closely associated with TMB-H status, MSI-H status, and superior ICI treatment response in several cancers, such as colorectal cancer, gastric cancer, and non-small cell lung cancer. These findings emphasize the necessity and importance of molecular-level detection and interpretation of SWI/SNF complex mutations.

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Cite This Study

Li et al. (2022) studied this question.

synapsesocial.com/papers/69d73eddc74376700bf310bb https://doi.org/10.1186/s12935-022-02757-x

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SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Key Points

Implication

Abstract

Discussion

Cite This Study

SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Key Points

Implication

Abstract

Discussion

Cite This Study

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