Determination of a Serum 25-Hydroxyvitamin D Reference Ranges in Japanese Adults Using Fully Automated Liquid Chromatography–Tandem Mass Spectrometry

February 3, 2023Journal of NutritionOpen Access

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Key Points

To establish accurate serum 25-hydroxyvitamin D reference ranges using automated liquid chromatography–tandem mass spectrometry and investigate potential lifestyle drivers of widespread insufficiency.
Applied fully automated liquid chromatography–tandem mass spectrometry to quantify serum 25-hydroxyvitamin D concentrations.
Assessed urban lifestyle factors, including reduced outdoor sunlight exposure and lower dietary intake of traditional foods, in relation to vitamin D status.
Identified a high prevalence of vitamin D insufficiency across seemingly healthy urban individuals.
Highlighted substantial discrepancies between official nutritional guidelines and observed blood concentrations, showing the necessity of validated clinical measurement platforms.

Cross-sectional study finds high vitamin D insufficiency rates in urban adults, indicating a need for standardized reference ranges.

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Miyamoto et al. (2023) studied this question.

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