What question did this study set out to answer?

To estimate the prevalence and correlates of low serum 25-hydroxyvitamin D among women in infertility clinics in Japan.

February 25, 2026Reproductive Medicine and BiologyOpen Access

Prevalence and Determinants of Low Serum Vitamin D Among Women Attending Infertility Clinics in Japan: A Real‐World Multicenter Cross‐Sectional Study

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Authors

KOKuniaki OtaKawasaki Medical School THToshihiro HabaraAkebono Clinic NKNobuo KoyamaKumamoto Orthopedic Surgery Hospital

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Implication

Multicenter cross-sectional study estimates low serum vitamin D prevalence in women attending infertility clinics, highlighting significant seasonal variations.

Key Points

To estimate the prevalence and correlates of low serum 25-hydroxyvitamin D among women in infertility clinics in Japan.
Conducted multicenter cross-sectional study of 17,261 women with measured 25(OH)D levels
Defined deficiency as < 20 ng/mL and insufficiency as < 30 ng/mL
Assessed monthly and seasonal variation in vitamin D levels
Applied multivariable logistic regression to evaluate correlates of deficiency
Compared vitamin D levels between supplement users and non-users
Median 25(OH)D level was 16.4 ng/mL with 66.8% deficient and 89.0% insufficient
Significant monthly and seasonal variation observed (p < 0.001)
Higher BMI associated with increased odds of vitamin D deficiency
Older age linked with lower odds of deficiency
Supplement users displayed higher 25(OH)D levels and a better vitamin D status distribution (p < 0.001)

Cite This Study

Ota et al. (2026) studied this question.

synapsesocial.com/papers/699e91eaf5123be5ed04fbd0 https://doi.org/10.1002/rmb2.70032

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Implication

Multicenter cross-sectional study estimates low serum vitamin D prevalence in women attending infertility clinics, highlighting significant seasonal variations.

Prevalence and Determinants of Low Serum Vitamin D Among Women Attending Infertility Clinics in Japan: A Real‐World Multicenter Cross‐Sectional Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevalence and Determinants of Low Serum Vitamin D Among Women Attending Infertility Clinics in Japan: A Real‐World Multicenter Cross‐Sectional Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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