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July 13, 2020Internal MedicineOpen Access

A Slight Decrease in the Serum Albumin Level Is Associated with the Rapid Progression of Kidney Dysfunction, Even within the Normal Range

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Why the study?

Does a lower serum albumin level, even within the normal range, predict a rapid decline in kidney function in the general population?

Population

11,000 participants in a voluntary health checkup program conducted between 1998 and 2006 in Japan.

Comparison

Lower serum albumin levels as an observational… vs Higher serum albumin levels (≥4.7 g/dL).

Design

Cohort

Authors

HAHoichi AmanoKYKazunobu YoshimuraRIRyutaro Iijima

Discussion

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Member takes

Overview

May identify higher kidney decline risk at normal albumin levels; leaves open clinical utility and causality in general populations.

Structured PICO

Does a lower serum albumin level, even within the normal range, predict a rapid decline in kidney function in the general population?

P
Population
11,000 participants in a voluntary health checkup program conducted between 1998 and 2006 in Japan.
I
Intervention
Lower serum albumin levels (≤4.3 g/dL and 4.4-4.6 g/dL) as an observational exposure.
C
Comparator
Higher serum albumin levels (≥4.7 g/dL).
O
Outcome
Difference in the estimated glomerular filtration rate (ΔeGFR) of ≥3 mL/min/1.73 m²/year.surrogate

A slight decrease in serum albumin, even within the normal range, is independently associated with a rapid decline in kidney function in the general population.

Cite This Study

Amano et al. (2020) studied this question.

synapsesocial.com/papers/69d7428aaa68b335b4f30c61https://doi.org/10.2169/internalmedicine.4466-20
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