Narrative review highlights dynamic shifts in Nrf2 gene regulatory networks during disease progression, indicating potential avenues for novel targeted therapies.
Additional computational and experimental studies are needed to obtain a more dynamic global view of Nrf2-mediated gene regulation. In particular, studies comparing how the Nrf2-dependent network changes from a physiological to a pathological condition can provide insight into mechanisms of disease and instruct new treatment strategies.
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Tonelli et al. (2017) studied this question.
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