Prospective study demonstrates omeprazole suspension prevents gastrointestinal bleeding and controls gastric pH in ventilated trauma patients, suggesting a safe, cost-effective prophylaxis.
In a prospective, evaluative study of 60 trauma patients who required mechanical ventilation and had at least one additional risk factor for stress ulcer development, omeprazole suspension prevented clinically significant gastrointestinal bleeding, maintained excellent control of gastric pH, produced no toxicity, and was the least costly medication alternative.
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Lasky et al. (1998) studied this question.
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