What question did this study set out to answer?

To evaluate the established hemagglutination inhibition protective titer benchmark (≥1:40) and compare its predictive performance against neuraminidase inhibition titers in protecting against influenza A/H1N1 disease.

April 20, 2016mBioOpen Access

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

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Authors

MMMatthew J. MemoliNational Institutes of Health PSPamela A. ShawKaiser Permanente Washington Health Research Institute AHAlison HanNational Institutes of Health Clinical Center

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Implication

Human challenge study demonstrates neuraminidase inhibition titers better predict protection against influenza A than standard hemagglutination titers, suggesting updated vaccine evaluation criteria.

Key Points

To evaluate the established hemagglutination inhibition protective titer benchmark (≥1:40) and compare its predictive performance against neuraminidase inhibition titers in protecting against influenza A/H1N1 disease.
Conducted a controlled wild-type influenza A/H1N1 virus challenge in healthy human volunteers.
Assessed baseline antihemagglutinin (HAI) and antineuraminidase (NAI) antibody titers in relation to subsequent influenza disease severity and protection.
While higher HAI titers predicted some protection against infection, NAI titers served as a significantly stronger independent predictor of disease reduction across all clinical aspects of influenza.
Identified NAI titer for the first time in a controlled human viral challenge study as an independent correlate of protection.

Cite This Study

Memoli et al. (2016) studied this question.

synapsesocial.com/papers/69d74d0df07a12db70b8a892 https://doi.org/10.1128/mbio.00417-16

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Implication

Human challenge study demonstrates neuraminidase inhibition titers better predict protection against influenza A than standard hemagglutination titers, suggesting updated vaccine evaluation criteria.

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

Discussion

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Implication

Key Points

Cite This Study

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

Discussion

Member takes

Implication

Key Points

Cite This Study

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