What question did this study set out to answer?

To elucidate the molecular mechanism connecting vitamin D deficiency to renin-angiotensin system activation and hypertension.

July 15, 2002Journal of Clinical InvestigationOpen Access

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

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To elucidate the molecular mechanism connecting vitamin D deficiency to renin-angiotensin system activation and hypertension.
Evaluated blood pressure, renin expression, and plasma angiotensin II levels in vitamin D receptor-null (VDR-null) and wild-type mice.
Assessed renin levels in wild-type mice following pharmacological inhibition or injection of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].
Investigated renin gene transcription in cell culture models treated with 1,25(OH)2D3 to determine receptor dependency and the role of calcium metabolism.
VDR-null mice exhibited severalfold elevations in renin expression and plasma angiotensin II production, resulting in hypertension, cardiac hypertrophy, and increased water intake despite intact salt- and volume-sensing mechanisms.
Inhibition of 1,25(OH)2D3 synthesis elevated renin expression in wild-type mice, whereas 1,25(OH)2D3 administration markedly suppressed renin production.
1,25(OH)2D3 directly repressed renin gene transcription through a VDR-mediated pathway independently of systemic calcium metabolism.

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Implication

Experimental study demonstrates that 1,25-dihydroxyvitamin D3 suppresses renin expression in mice, indicating vitamin D analogues may help prevent hypertension.

Cite This Study

Li et al. (2002) studied this question.

synapsesocial.com/papers/69d75036f182769aa8b8a3a3 https://doi.org/10.1172/jci15219

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Implication

Experimental study demonstrates that 1,25-dihydroxyvitamin D3 suppresses renin expression in mice, indicating vitamin D analogues may help prevent hypertension.

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

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Discussion

Implication

Cite This Study

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

Key Points

Discussion

Implication

Cite This Study

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