Key result
Vitamin D deficiency is linked to RAAS dysregulation and altered renin-aldosterone modulation in hypertension.
This narrative review highlights the potential regulatory role of vitamin D in the renin-angiotensin-aldosterone system and its implications for blood pressure control, while noting conflicting results in human studies.
Both hyperaldosteronism and vitamin D deficiency are associated with increased cardiovascular morbidity and mortality. Evidence from animal studies highlights the regulatory role of vitamin D in the renin-angiotensin-aldosterone system (RAAS) and its implications for blood pressure control. However, human studies have yielded conflicting results. This narrative review presents a conceptual framework linking vitamin D deficiency to RAAS dysregulation in hypertension, emphasizing systemic and local regulatory mechanisms. We discuss the effects of vitamin D on renin suppression, aldosterone modulation, and parathyroid hormone interactions, as well as confounding factors contributing to variability in findings. Finally, we outline research priorities, including thresholds for vitamin D deficiency, genetic influences, and interventional strategies, to better understand this critical axis.
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Loh et al. (2025) conducted a review in Hypertension. Vitamin D deficiency was evaluated. Vitamin D deficiency is linked to renin-angiotensin-aldosterone system dysregulation in hypertension, with effects on renin suppression and aldosterone modulation.
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