Experimental study demonstrates efficient palladium-catalyzed cross-coupling of potassium alkenyltrifluoroborates with aryl and alkenyl electrophiles, indicating a robust method for organic synthesis.
[reaction: see text] The palladium-catalyzed coupling reaction of potassium alkenyltrifluoroborates with aryl or alkenyl halides or triflates proceeds readily with good yields. The trifluoroborates are air- and moisture-stable solids that can be stored indefinitely. The cross-coupling can be effected using PdCl(2)(dppf).CH(2)Cl(2) as the catalyst in n-PrOH in the presence of Et(3)N. A variety of functional groups are tolerated.
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Molander et al. (2001) studied this question.
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