What question did this study set out to answer?

Review the function of the Sonic Hedgehog pathway across postnatal development and adult lung injury to determine whether its activation drives disease or mediates tissue repair.

July 28, 2014American Journal of Respiratory Cell and Molecular BiologyOpen Access

Sonic Hedgehog Signaling in the Lung. From Development to Disease

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Authors

MKMatthias C. KuglerNew York University AJAlexandra L. JoynerKettering University CLCynthia A. LoomisBreast Cancer Research Foundation

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Implication

Review examines Sonic Hedgehog signaling across lung development, injury, and disease in respiratory tissue, highlighting its therapeutic potential and complex epithelial-mesenchymal crosstalk.

Key Points

Review the function of the Sonic Hedgehog pathway across postnatal development and adult lung injury to determine whether its activation drives disease or mediates tissue repair.
Synthesized molecular and clinical literature on Sonic Hedgehog signaling in lung organogenesis, postnatal stages, and adult chronic lung pathologies.
Compared epithelial-mesenchymal interplay during fibrotic lung repair with injury responses observed in other organ systems.
Critically appraised experimental tools and pharmacological agents currently used to monitor and modulate Hedgehog pathway activity.
Sonic Hedgehog serves as an indispensable morphogen guiding epithelial-mesenchymal crosstalk during airway and alveolar development.
Aberrant reactivation of Hedgehog signaling occurs consistently across adult lung disorders, including pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, and lung cancer.
Epithelial-mesenchymal injury responses display both conserved and organ-specific signaling dynamics that dictate whether pathway reactivation is protective or pathogenic.

Cite This Study

Kugler et al. (2014) studied this question.

synapsesocial.com/papers/69d75410b54ccf0cfef30dfa https://doi.org/10.1165/rcmb.2014-0132tr

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Implication

Review examines Sonic Hedgehog signaling across lung development, injury, and disease in respiratory tissue, highlighting its therapeutic potential and complex epithelial-mesenchymal crosstalk.

Sonic Hedgehog Signaling in the Lung. From Development to Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Sonic Hedgehog Signaling in the Lung. From Development to Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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