January 30, 2017European Heart Journal146 citationsOpen Access

Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome

DADeniz Akdiş ASArdan M. Saguner KSKhooshbu Shah

Structured PICO

Are elevated serum testosterone levels in males and decreased estradiol levels in females associated with MACE in patients with ARVC/D?

Population

Patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) and a stem cell derived cardiomyocyte-based model

Intervention

Elevated serum testosterone levels in males and decreased estradiol levels in females (biomarker exposure)

Outcome

Major adverse cardiovascular events (MACE) and disease pathologycomposite

Sex hormone levels are independently associated with MACE in ARVC/D, suggesting a potential role in risk stratification and targeted preventive interventions.

Abstract

Elevated serum testosterone levels in males and decreased estradiol levels in females are independently associated with MACE in ARVC/D, and directly influence disease pathology. Therefore, determining the levels of sex hormones may be useful for risk stratification and may open a new window for preventive interventions.

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