What question did this study set out to answer?

Determine whether diffusion basis spectrum imaging can resolve the confounding effects of inflammation and edema to quantitatively assess axonal injury, demyelination, and cellularity.

December 1, 2011BrainOpen Access

Quantification of increased cellularity during inflammatory demyelination

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Authors

YWYong WangXuzhou Medical College QWQing WangXinjiang Medical University JHJustin P. HaldarUniversity of Southern California

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Implication

Preclinical imaging study demonstrates accurate quantification of cellularity and demyelination in cuprizone-treated mice, highlighting diffusion basis spectrum imaging as a potential biomarker.

Key Points

Determine whether diffusion basis spectrum imaging can resolve the confounding effects of inflammation and edema to quantitatively assess axonal injury, demyelination, and cellularity.
Assessed baseline cellularity with and without vasogenic edema using tissue phantoms composed of fixed mouse trigeminal nerves juxtaposed with or without gel.
Performed in vivo diffusion basis spectrum imaging (DBSI) alongside standard diffusion tensor imaging (DTI) on the corpus callosum of cuprizone-treated mice.
Validated imaging metrics against histological analyses of cell nuclei counts, axonal damage, and demyelination via immunohistochemistry.
DBSI successfully separated cellularity and grey matter contamination, detecting immunohistochemistry-confirmed axonal injury and demyelination in the corpus callosum that DTI failed to identify.
Cellularity measurements derived from DBSI demonstrated a strong positive correlation with cell nuclei counts verified by immunohistochemistry.

Cite This Study

Wang et al. (2011) studied this question.

synapsesocial.com/papers/69d754daef4aa71f97f30c66 https://doi.org/10.1093/brain/awr307

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Implication

Preclinical imaging study demonstrates accurate quantification of cellularity and demyelination in cuprizone-treated mice, highlighting diffusion basis spectrum imaging as a potential biomarker.

Quantification of increased cellularity during inflammatory demyelination

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantification of increased cellularity during inflammatory demyelination

Discussion

Member takes

Implication

Key Points

Cite This Study

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