What question did this study set out to answer?

To examine the variability in clinical onset, symptom progression, and functional impairment among patients presenting with parkinsonism.

May 1, 1967NeurologyOpen Access

Parkinsonism

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Authors

MHMargaret M. HoehnUniversity of Colorado Denver MYMelvin D. YahrIcahn School of Medicine at Mount Sinai

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Implication

Observational analysis reveals marked clinical diversity in parkinsonism progression, highlighting the need for natural history data to evaluate therapies.

Key Points

To examine the variability in clinical onset, symptom progression, and functional impairment among patients presenting with parkinsonism.
Evaluated clinical presentation, age of onset, cardinal signs, and functional disability across patient cohorts with parkinsonism.
Substantial heterogeneity exists regarding age of onset, presentation of cardinal symptoms, and rates of functional decline.
Scarcity of longitudinal natural history data compounded by broad clinical diversity impairs objective assessment of therapeutic interventions.

Cite This Study

Hoehn et al. (1967) studied this question.

synapsesocial.com/papers/69d755dcb4cef8fedc48f65e https://doi.org/10.1212/wnl.17.5.427

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Implication

Observational analysis reveals marked clinical diversity in parkinsonism progression, highlighting the need for natural history data to evaluate therapies.

Parkinsonism

Discussion

Member takes

Implication

Key Points

Cite This Study

Parkinsonism

Discussion

Member takes

Implication

Key Points

Cite This Study

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