Tranexamic Acid in Patients Undergoing Noncardiac Surgery
Why the study?
Does tranexamic acid reduce composite bleeding outcomes in patients undergoing noncardiac surgery?
Population
Patients undergoing noncardiac surgery
Comparison
Tranexamic acid vs placebo
Authors
Discussion
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Member takes
Implication
Reduces bleeding in noncardiac surgery; cardiovascular noninferiority not established, leaving safety unresolved for further trials.
Structured PICO
Does tranexamic acid reduce composite bleeding outcomes in patients undergoing noncardiac surgery?
P
Population
Patients undergoing noncardiac surgery
I
Intervention
Tranexamic acid
C
Comparator
Placebo
O
Outcome
Composite bleeding outcome and composite cardiovascular outcomecomposite
In patients undergoing noncardiac surgery, tranexamic acid reduces bleeding but its cardiovascular safety (noninferiority) compared to placebo was not definitively established.
Cite This Study
Devereaux et al. (2022) studied this question.