Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours

Lina Palaiodimou; Aristeidis H. Katsanos; Guillaume Turc; Alexandros‐Georgios Asimakopoulos; Dimitris Mavridis; Peter D. Schellinger; Aikaterini Theodorou; Robin Lemmens; Simona Sacco; Apostolοs Safouris; Mira Katan; Amrou Sarraj; Urs Fischer; Georgios Tsivgoulis

doi:10.1212/wnl.0000000000209903

October 16, 2024NeurologyOpen Access

Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours

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Key Points

To compare the efficacy and safety of tenecteplase (0.25 mg/kg) versus alteplase in acute ischemic stroke within 4.5 hours of symptom onset.
Conducted an updated meta-analysis comparing tenecteplase at a dose of 0.25 mg/kg against alteplase in acute ischemic stroke treated within 4.5 hours.
Evaluated functional outcomes, disability status at 3 months, and overall safety profiles.
Tenecteplase (0.25 mg/kg) showed superiority over alteplase for achieving excellent functional outcome and reduced disability at 3 months.
Safety outcomes were similar between tenecteplase and alteplase, with no reported increase in safety complications.

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Implication

Meta-analysis shows superior functional recovery with tenecteplase over alteplase in acute ischemic stroke, supporting transitioning clinical practice.

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Cite This Study

Palaiodimou et al. (2024) studied this question.

synapsesocial.com/papers/69d75a0caa68b335b4f31106 https://doi.org/10.1212/wnl.0000000000209903

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Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours

Key Points

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Implication

Abstract

Discussion

Cite This Study

Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours

Key Points

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Implication

Abstract

Discussion

Cite This Study

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