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Implication
Review outlines the physical mechanisms and biological impacts of the nanoparticle protein corona, highlighting key design strategies for future nanomedicines.
Key Points
- To review a decade of research into the protein corona and examine its implications for biological interactions, nanomedicine, and bio-nano engineering.
- Synthesized ten years of experimental, computational, and theoretical literature on nanoparticle-protein interactions across in vitro and in vivo models.
- Characterized the physical mechanisms, dynamic time evolution, and environment-dependent variations of the protein corona between in vitro and in vivo biological systems.
- Assessed polymer-based stealth functionalization strategies designed to suppress non-specific protein adsorption and evaluated computational models of biocorona formation.
- Identified critical gaps and strategic engineering priorities for controlling the bio-nano interface in translational nanomedicine over the coming decade.
Cite This Study
Ke et al. (2017) studied this question.