What question did this study set out to answer?

To review the signaling pathways and molecular structures that regulate intestinal epithelial barrier integrity and to characterize how barrier breakdown contributes to human disease.

August 1, 2018SHILAP Revista de lepidopterologíaOpen Access

Mechanisms regulating intestinal barrier integrity and its pathological implications

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Authors

CCChaithanya ChelakkotSeoul National University JGJaewang GhimPohang University of Science and Technology SRSung Ho RyuPohang University of Science and Technology

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Implication

Review reveals mechanisms regulating intestinal barrier integrity across epithelial tissues, suggesting therapeutic targets for inflammatory and metabolic disorders.

Key Points

To review the signaling pathways and molecular structures that regulate intestinal epithelial barrier integrity and to characterize how barrier breakdown contributes to human disease.
Synthesized molecular evidence on epithelial tight junction assemblies, including claudins, occludin, and zonula occludens complexes.
Assessed regulatory stimuli governing barrier function, such as intracellular signaling cascades, cytokines, small GTPases, and post-translational modifications.
Analyzed literature connecting epithelial barrier disruption to the pathogenesis of inflammatory bowel disease, obesity, and systemic metabolic disorders.
Tight junction protein complexes dynamically control paracellular permeability in response to cytokine signaling, small GTPase activity, and post-translational modifications.
Loss of intestinal barrier integrity permits aberrant luminal antigen permeation, driving sustained immune activation in inflammatory bowel disease and metabolic pathology.
Delineating molecular pathways that govern junction assembly provides candidate targets for therapeutic interventions aimed at restoring mucosal barrier function.

Cite This Study

Chelakkot et al. (2018) studied this question.

synapsesocial.com/papers/69d75c3ef182769aa8b8aa27 https://doi.org/10.1038/s12276-018-0126-x

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Implication

Review reveals mechanisms regulating intestinal barrier integrity across epithelial tissues, suggesting therapeutic targets for inflammatory and metabolic disorders.

Mechanisms regulating intestinal barrier integrity and its pathological implications

Discussion

Member takes

Implication

Key Points

Cite This Study

Mechanisms regulating intestinal barrier integrity and its pathological implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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