Population
Single living heart (cardiomyocytes) and skeletal muscle (soleus fibers) cells
Comparison
Fluorescence recovery after photobleaching… vs Radial vs longitudinal diffusion, heart vs…
Design
Preclinical
Authors
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Myoglobin diffusion contributes <2% to cardiac O2 transport under load; leaves open its role in human myocardium.
Intracellular diffusivity of myoglobin is very low in striated muscle cells, contributing less than 2% to overall intracellular oxygen transport in the heart under high work load.
Papadopoulos et al. (2001) studied this question.
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