What question did this study set out to answer?

To review the principles of cellular self-organization and outline the applications of three-dimensional stem cell-derived organoid technologies in biomedical research.

July 17, 2014Science

Organogenesis in a dish: Modeling development and disease using organoid technologies

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Authors

MLMadeline A. LancasterMRC Laboratory of Molecular Biology JKJuergen A. KnoblichInstitute of Molecular Biotechnology

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Implication

Review highlights stem cell-derived three-dimensional organoid models for human development and disease, suggesting transformative applications in drug screening and regenerative medicine.

Key Points

To review the principles of cellular self-organization and outline the applications of three-dimensional stem cell-derived organoid technologies in biomedical research.
Synthesized historical foundations of vertebrate cellular self-organization and modern advances in 3D culture systems.
Evaluated generation strategies using adult tissue stem cells, embryonic stem cells, and patient-derived induced pluripotent stem cells.
Dissociated vertebrate stem cells maintain an inherent self-organizing capacity to reassemble into complex, organotypic architectural structures in vitro.
Stem cell-derived organoids successfully recapitulate human development and pathology, providing robust platforms for toxicology screening and future tissue replacement therapies.

Cite This Study

Lancaster et al. (2014) studied this question.

synapsesocial.com/papers/69d75fc6ef4aa71f97f30f25 https://doi.org/10.1126/science.1247125

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Implication

Review highlights stem cell-derived three-dimensional organoid models for human development and disease, suggesting transformative applications in drug screening and regenerative medicine.

Organogenesis in a dish: Modeling development and disease using organoid technologies

Discussion

Member takes

Implication

Key Points

Cite This Study

Organogenesis in a dish: Modeling development and disease using organoid technologies

Discussion

Member takes

Implication

Key Points

Cite This Study

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