What question did this study set out to answer?

The aim is to derive a sample-size formula for testing the equality of two survival distributions using concomitant information.

June 1, 1983Biometrics

Sample-Size Formula for the Proportional-Hazards Regression Model

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Formula derives the necessary observations for testing survival distributions, aiding clinical trial design.

The aim is to derive a sample-size formula for testing the equality of two survival distributions using concomitant information.
Derivation of a formula for sample size based on the proportional-hazards model.
Extension of Schoenfeld's asymptotic power results to incorporate concomitant information.
Computation of loss of efficiency due to the omission of concomitant variables.
The derived formula specifies the necessary sample size for adequate statistical power.
Incorporating concomitant information significantly improves estimation accuracy.
The analysis quantifies efficiency loss when ignoring relevant variables.

David Schoenfeld (1983) studied this question.

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