Why the study?
Does advanced age attenuate nitric oxide- and axon reflex-mediated cutaneous vasodilation during local heating?
Population
20 healthy men and women, comprising 10 young (22 +/- 2 yr) and 10 older (77 +/- 5 yr) subjects.
Comparison
Local heating of forearm skin to 42 degrees C… vs Young subjects compared to older subjects.
Design
Cross-sectional
Authors
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Age-associated attenuation of cutaneous vasodilation supports impaired NO- and axon reflex mechanisms; hypothesis-generating and should not yet change practice.
Does advanced age attenuate nitric oxide- and axon reflex-mediated cutaneous vasodilation during local heating?
Advanced age is associated with attenuated cutaneous vasodilator responses to local heating, driven by reductions in both axon reflex-mediated and nitric oxide-mediated vasodilation.
Minson et al. (2002) studied this question.
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