What question did this study set out to answer?

Summarize the regulatory signaling functions of major growth factors and cytokines in cutaneous wound repair and evaluate current and emerging clinical delivery approaches.

September 1, 2008Wound Repair and Regeneration

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

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Authors

SBStephan BarrientosMedical City Dallas Hospital OSOlivera StojadinovićUniversity of Miami MGMichael S. GolinkoMonroe Carell Jr. Children's Hospital

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Implication

Expert review outlines the regulatory roles of growth factors and cytokines in skin repair, highlighting emerging delivery systems and therapies for wound healing.

Key Points

Summarize the regulatory signaling functions of major growth factors and cytokines in cutaneous wound repair and evaluate current and emerging clinical delivery approaches.
Reviewed biological mechanisms and cell-signaling pathways involving EGF, TGF-beta, FGF, VEGF, GM-CSF, PDGF, CTGF, ILs, and TNF-alpha during tissue regeneration.
Assessed clinical application statuses of therapeutic growth factors and current advances in gene therapy and biomaterial delivery vehicles (polymers, fibrin mesh, collagen).
PDGF-BB, bFGF, and GM-CSF represent the primary growth factor therapies currently used in patients, with PDGF-BB being the only agent to successfully complete randomized clinical trials in the United States.
Novel delivery platforms including gene therapy and biodegradable biomaterials demonstrate potential to improve growth factor stability and bioavailability in clinical wound management.

Cite This Study

Barrientos et al. (2008) studied this question.

synapsesocial.com/papers/69d761d6ef4aa71f97f310d2 https://doi.org/10.1111/j.1524-475x.2008.00410.x

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Implication

Expert review outlines the regulatory roles of growth factors and cytokines in skin repair, highlighting emerging delivery systems and therapies for wound healing.

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

Discussion

Member takes

Implication

Key Points

Cite This Study

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

Discussion

Member takes

Implication

Key Points

Cite This Study

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