Leisure-time physical activity and DNA methylation age—a twin study
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Implication
Twin study reveals minimal impact of leisure-time physical activity on DNA methylation age acceleration in adults, suggesting genetic factors largely drive biological aging rates.
Key Points
- To evaluate the influence of leisure-time physical activity during adulthood on DNA methylation age acceleration while accounting for genetic background.
- Analyzed twin pairs across different age groups to distinguish genetic influences from non-shared environmental factors affecting epigenetic aging.
- Evaluated the association between adult leisure-time physical activity habits and DNA methylation age acceleration after controlling for shared familial and genetic factors.
- Non-shared environmental factors explained a larger amount of variance in DNA methylation age acceleration in older individuals compared to younger individuals.
- Leisure-time physical activity throughout adult years exhibited at most a minor effect on DNA methylation age acceleration after adjusting for genetic factors.
Cite This Study
Sillanpää et al. (2019) studied this question.