Why the study?
Does adiponectin signaling regulate myocardial oxidative stress in humans?
Does adiponectin signaling regulate myocardial oxidative stress in humans?
This study provides the first evidence in humans of a mutual regulatory mechanism between epicardial adipose tissue and the heart to defend against oxidative stress via adiponectin.
Answers are grounded in this paper and cite their sources.
Supports investigation of adiponectin to mitigate cardiac oxidative stress; leaves open clinical translation pending prospective studies.
We demonstrate for the first time in humans that adiponectin directly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or paracrine effects. Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress.
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Antonopoulos et al. (2016) studied this question.
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