What question did this study set out to answer?

To evaluate the validity and predictive value of the fractional inhibitory concentration (FIC) index for assessing antibiotic synergy using blinded experimental controls.

January 1, 1983Journal of Antimicrobial Chemotherapy

The fractional inhibitory concentration (FIC) index as a measure of synergy

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To evaluate the validity and predictive value of the fractional inhibitory concentration (FIC) index for assessing antibiotic synergy using blinded experimental controls.
Conducted fully blind in vitro experiments evaluating combinations of the antibacterial agents alafosfalin and cephalexin, including controls where agents were combined with themselves.
Assessed interaction magnitude across FIC index ranges and evaluated the graphical representation of synergy using average isobolograms.
Weak antibacterial interactions with an FIC index between 0.5 and 0.99 were statistically highly significant under controlled conditions.
Average isobologram representations provided informative value only for antibiotic combinations demonstrating moderate to strong interaction.

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Implication

Blinded in vitro study reveals statistically significant synergy at weak FIC index thresholds in antibacterial combinations, suggesting rigorous blinding is essential for synergy claims.

Cite This Study

Hall et al. (1983) studied this question.

synapsesocial.com/papers/69d766e4aa68b335b4f31483 https://doi.org/10.1093/jac/11.5.427

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Implication

Blinded in vitro study reveals statistically significant synergy at weak FIC index thresholds in antibacterial combinations, suggesting rigorous blinding is essential for synergy claims.

The fractional inhibitory concentration (FIC) index as a measure of synergy

Key Points

Discussion

Implication

Cite This Study

The fractional inhibitory concentration (FIC) index as a measure of synergy

Key Points

Discussion

Implication

Cite This Study

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