What question did this study set out to answer?

To analyze the cellular, ultrastructural, and kinetic characteristics of childhood vascular lesions in order to establish a biologically valid classification system.

March 1, 1982Plastic & Reconstructive Surgery

Hemangiomas and Vascular Malformations in Infants and Children

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Authors

JMJohn B. MullikenUniversité Paris-Sud JGJulie GlowackiBrigham and Women's Hospital

Discussion

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Implication

Histological analysis demonstrates distinct cellular kinetics separating hemangiomas from vascular malformations in pediatric specimens, highlighting clear criteria for clinical management.

Key Points

To analyze the cellular, ultrastructural, and kinetic characteristics of childhood vascular lesions in order to establish a biologically valid classification system.
Analyzed 49 pediatric vascular lesion specimens using histology, electron microscopy, and [3H]thymidine incorporation to evaluate endothelial cell proliferation and differentiation markers.
Categorized specimens based on clinical history and morphology into proliferating hemangiomas (n=14), involuting hemangiomas (n=12), and vascular malformations (n=23).
Proliferating hemangiomas showed significant endothelial hyperplasia, multilaminated basement membranes, and active [3H]thymidine incorporation, whereas involuting hemangiomas demonstrated fibrosis, fat deposition, and low-to-absent cellular labeling.
Endothelial cells in hemangiomas expressed markers of differentiation, including Weibel-Palade bodies, alkaline phosphatase, and factor VIII production.
Vascular malformations exhibited no [3H]thymidine incorporation, normal ultrastructure, and dysplastic capillary, arterial, venous, or lymphatic vessels that grew commensurately with the child without cellular proliferation.

Cite This Study

Mulliken et al. (1982) studied this question.

synapsesocial.com/papers/69d766e4ef4aa71f97f3124d https://doi.org/10.1097/00006534-198203000-00002

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March 1, 1982Plastic & Reconstructive Surgery

Hemangiomas and Vascular Malformations in Infants and Children

View Full Paper

Ask AI

Bookmark

Authors

JMJohn B. MullikenUniversité Paris-Sud JGJulie GlowackiBrigham and Women's Hospital

Discussion

Member takes

Implication

Histological analysis demonstrates distinct cellular kinetics separating hemangiomas from vascular malformations in pediatric specimens, highlighting clear criteria for clinical management.

Key Points

To analyze the cellular, ultrastructural, and kinetic characteristics of childhood vascular lesions in order to establish a biologically valid classification system.
Analyzed 49 pediatric vascular lesion specimens using histology, electron microscopy, and [3H]thymidine incorporation to evaluate endothelial cell proliferation and differentiation markers.
Categorized specimens based on clinical history and morphology into proliferating hemangiomas (n=14), involuting hemangiomas (n=12), and vascular malformations (n=23).
Proliferating hemangiomas showed significant endothelial hyperplasia, multilaminated basement membranes, and active [3H]thymidine incorporation, whereas involuting hemangiomas demonstrated fibrosis, fat deposition, and low-to-absent cellular labeling.
Endothelial cells in hemangiomas expressed markers of differentiation, including Weibel-Palade bodies, alkaline phosphatase, and factor VIII production.
Vascular malformations exhibited no [3H]thymidine incorporation, normal ultrastructure, and dysplastic capillary, arterial, venous, or lymphatic vessels that grew commensurately with the child without cellular proliferation.

Cite This Study

Mulliken et al. (1982) studied this question.

synapsesocial.com/papers/69d766e4ef4aa71f97f3124d https://doi.org/10.1097/00006534-198203000-00002

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