Why the study?
Does intracoronary pyruvate infusion improve regional ventricular function in normal and stunned myocardium in a canine model?
Population
8 chloralose/urethane anesthetized dogs instrumented with ultrasonic crystals
Comparison
Pyruvate infused directly into the left anterior… vs Pre-infusion baseline measurements in normal and…
Design
Preclinical
Follow-up
Up to 20 minutes after cessation of pyruvate infusion
Authors
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Pyruvate may augment function in stunned myocardium; animal data leave translation to human postischemic hearts unresolved.
Does intracoronary pyruvate infusion improve regional ventricular function in normal and stunned myocardium in a canine model?
Intracoronary pyruvate exerts a positive inotropic effect, rapidly but transiently improving regional ventricular function in both normal and postischemic stunned myocardium.
Mentzer et al. (1989) studied this question.
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