Why the study?
Does inotropic stimulation with dopamine improve segmental function in ischemic and reperfused myocardium in a dog model?
Population
15 dogs undergoing coronary artery occlusion and reperfusion
Comparison
Inotropic stimulation with dopamine vs No inotropic stimulation (spontaneous recovery)
Design
Preclinical
Authors
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May support dopamine for reversible post-reperfusion stunning in animals; leaves open translation to human ischemia-reperfusion injury.
Does inotropic stimulation with dopamine improve segmental function in ischemic and reperfused myocardium in a dog model?
Inotropic stimulation effectively enhances mechanical function in reperfused, viable myocardium, suggesting a potential treatment for pump failure caused by reversible ischemia.
Mercier et al. (1982) studied this question.
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