Population
Anaesthetised open-chest dogs subjected to 10 minutes of coronary occlusion and subsequent reperfusion
Comparison
Pharmacological agents including intracoronary… vs Baseline function and untreated reperfusion…
Design
Preclinical
Follow-up
10 minutes of ischemia followed by 15 minutes of reperfusion
Authors
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Supports calcium overload in reperfusion stunning in animals; leaves open translation to human cardioprotection trials.
Depressed contractile function in reperfused myocardium is likely driven by calcium overload during reperfusion rather than residual ischemia.
H. J SMITH (1980) studied this question.
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