What question did this study set out to answer?

To assess the clinical yield and mutational profile of multi-gene panel testing in Asian patients presenting with multiple primary cancers compared to those with single cancers.

July 17, 2018OncotargetOpen Access

Clinical genetic testing outcome with multi-gene panel in Asian patients with multiple primary cancers

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To assess the clinical yield and mutational profile of multi-gene panel testing in Asian patients presenting with multiple primary cancers compared to those with single cancers.
Evaluated outcomes of multi-gene panel testing for pathogenic and deleterious germline mutations in an Asian patient cohort with multiple primary cancers versus single primary cancers.
Patients diagnosed with multiple primary cancers showed a higher likelihood of carrying pathogenic mutations than individuals with a single cancer.
Approximately 75% of deleterious mutations in patients with multiple primary cancers were localized to BRCA1/2 and mismatch repair genes.
Multi-gene panel testing enabled the identification of pathogenic mutations across an additional six genes beyond BRCA1/2 and mismatch repair genes.

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Implication

Observational study reveals elevated pathogenic mutation rates in Asian patients with multiple primary cancers, highlighting the clinical value of multi-gene panel testing.

Cite This Study

Chan et al. (2018) studied this question.

synapsesocial.com/papers/69d76a67b843b2be9948fa5a https://doi.org/10.18632/oncotarget.25769

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Implication

Observational study reveals elevated pathogenic mutation rates in Asian patients with multiple primary cancers, highlighting the clinical value of multi-gene panel testing.

Clinical genetic testing outcome with multi-gene panel in Asian patients with multiple primary cancers

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Discussion

Implication

Cite This Study

Clinical genetic testing outcome with multi-gene panel in Asian patients with multiple primary cancers

Key Points

Discussion

Implication

Cite This Study

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