February 1, 1995The Journal of Cell BiologyOpen Access

Mechanical function of dystrophin in muscle cells.

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Why the study?

Does the presence of dystrophin increase the mechanical stiffness of muscle cells?

Population

Myotubes cultured from mdx mice and normal controls

Comparison

Normal dystrophin expression vs Lack of dystrophin (mdx mutation)

Design

Preclinical

Authors

CPCarmela PasternakWashington University in St. Louis SWSiew Ying WongNational University of Singapore EEE L ElsonUniversity of Washington

Discussion

Member takes

Implication

Supports dystrophin-mediated stiffness in mdx models; hypothesis-generating for DMD membrane therapies pending human data.

Structured PICO

Does the presence of dystrophin increase the mechanical stiffness of muscle cells?

Population

Myotubes cultured from mdx mice (a model for Duchenne muscular dystrophy lacking dystrophin) and normal controls

Intervention

Normal dystrophin expression

Comparator

Lack of dystrophin (mdx mutation)

Outcome

Local stiffness of the membrane skeleton (increment of force per micron of indentation)surrogate

Dystrophin significantly increases the mechanical stiffness of the muscle cell membrane skeleton, suggesting its role in protecting myofibers from disruption during contraction.

Cite This Study

Pasternak et al. (1995) studied this question.

synapsesocial.com/papers/69d76caddb9d5e1bf4b8a5a3 https://doi.org/10.1083/jcb.128.3.355

View Full Paper

Ask AI

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Mechanical function of dystrophin in muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanical function of dystrophin in muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider