Population
mdx (X-linked muscular dystrophy) mice (dystrophin-deficient muscle fibers)
Design
Preclinical
Authors
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Hypothesis-generating for dystrophin-targeted therapies in dystrophy; leaves open human cardiac translation without clinical validation.
Dystrophin provides mechanical reinforcement to the sarcolemma, protecting it from membrane stresses developed during muscle contraction.
Petrof et al. (1993) studied this question.
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