May 22, 1992Proceedings of the Royal Society B Biological Sciences

Abnormalities in structure and function of limb skeletal muscle fibres of dystrophic mdx mice

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Population

Adult (older than 26 weeks) dystrophic mdx mice and normal mice

Comparison

Mild protocol of lengthening contractions vs Normal soleus, normal EDL, and mdx soleus…

Design

Preclinical

Authors

SHStewart I. HeadCamden and Campbelltown Hospitals DWDavid A. WilliamsForest Institute DSD. George StephensonLa Trobe University

Discussion

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Implication

Indicates mdx fast-fiber vulnerability to mild injury; leaves open translation to DMD exercise guidance.

Structured PICO

Population

Adult (older than 26 weeks) dystrophic mdx mice and normal mice

Intervention

Mild protocol of lengthening (eccentric) contractions (muscle stretched by 12% during a tetanic contraction)

Comparator

Normal soleus, normal EDL, and mdx soleus muscles subjected to the same protocol

Outcome

Maximal tetanic force production and structural deformities of skeletal muscle fibressurrogate

Deformed fast glycolytic fibres in adult mdx EDL muscles are highly susceptible to damage from mild lengthening contractions, leading to reduced tetanic force.

Cite This Study

Head et al. (1992) studied this question.

synapsesocial.com/papers/69d76caddb9d5e1bf4b8a5a5 https://doi.org/10.1098/rspb.1992.0058

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Abnormalities in structure and function of limb skeletal muscle fibres of dystrophic mdx mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Abnormalities in structure and function of limb skeletal muscle fibres of dystrophic mdx mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider