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Mechanistic study reveals that PICH promotes cyclin A1 transcription and drives chemoresistance in gastric cancer, highlighting a novel therapeutic target.
PICH binds Pol II and ATF4 in an ATPase-dependent manner to form a transcriptional complex that promotes cyclin A1 expression, accelerates S-phase progression, and impairs 5-FU chemosensitivity in gastric cancer.
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Ye et al. (2023) studied this question.
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