Why the study?
Does regional citrate and calcium anticoagulation prolong continuous renal replacement therapy circuit life compared to regional heparin and protamine anticoagulation in critically ill adults?
Population
Critically ill adults requiring continuous renal replacement therapy
Comparison
Regional citrate and calcium anticoagulation vs Regional heparin and protamine anticoagulation
Design
RCT, Randomized
Authors
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Supports preferring regional citrate anticoagulation for CRRT to extend circuit life and reduce adverse events; challenges prior low-certainty evidence against benefit.
Does regional citrate and calcium anticoagulation prolong continuous renal replacement therapy circuit life compared to regional heparin and protamine anticoagulation in critically ill adults?
Regional citrate anticoagulation prolongs CRRT circuit life and reduces adverse events compared to regional heparin in critically ill adults.
Gattas et al. (2015) studied this question.
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