The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTThe Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug CandidatesStephen D. Roughley*‡ and Allan M. Jordan§View Author Information‡ Vernalis (R&D) Ltd., Granta Park, Cambridge, CB21 6GB, U.K.§ Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, U.K.*Phone: (+44) 01223 895555. Fax: (+44) 01223 895556. E-mail: email protectedCite this: J. Med. Chem. 2011, 54, 10, 3451–3479Publication Date (Web):April 19, 2011Publication History Received18 February 2011Published online2 May 2011Published inissue 26 May 2011https://pubs.acs.org/doi/10.1021/jm200187yhttps://doi.org/10.1021/jm200187yreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views51874Altmetric-Citations2000LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Amides,Amines,Aromatic compounds,Chemical reactions Get e-Alerts