What question did this study set out to answer?

To evaluate whether a non-narcotic combination of medetomidine, midazolam, and butorphanol can serve as an effective substitute for ketamine in murine surgical anesthesia.

January 1, 2011EXPERIMENTAL ANIMALSOpen Access

Effect of Three Types of Mixed Anesthetic Agents Alternate to Ketamine in Mice

View Full Paper

Ask AI

Bookmark

Authors

SKS KawaiMeijo University YTYasuhiro TakagiMukogawa Women's University SKShiro KanekoThe University of Osaka

Discussion

Member takes

Implication

Animal study shows a medetomidine, midazolam, and butorphanol mixture matches ketamine-xylazine anesthesia duration in mice, indicating a viable alternative without narcotic licensing.

Key Points

To evaluate whether a non-narcotic combination of medetomidine, midazolam, and butorphanol can serve as an effective substitute for ketamine in murine surgical anesthesia.
Administered an intraperitoneal combination of medetomidine (0.3 mg/kg), midazolam (4.0 mg/kg), and butorphanol (5.0 mg/kg) (M/M/B: 0.3/4/5) to male ICR mice.
Assessed anesthetic depth and duration from loss to recovery of the righting reflex by scoring tail pinch, corneal, and forelimb and hindlimb pedal withdrawal reflexes.
Surgical anesthesia duration achieved with M/M/B (0.3/4/5 mg/kg) was almost identical to the surgical anesthetic duration provided by a standard ketamine and xylazine mixture (80/8 mg/kg).
Cumulative reflex scoring confirmed that M/M/B induced sufficient anesthetic depth for murine surgical procedures without requiring ketamine or pentobarbital.

Cite This Study

Kawai et al. (2011) studied this question.

synapsesocial.com/papers/69d7707fb1cb92dd1bb8b341 https://doi.org/10.1538/expanim.60.481

View Full Paper

Ask AI

Bookmark

Implication

Animal study shows a medetomidine, midazolam, and butorphanol mixture matches ketamine-xylazine anesthesia duration in mice, indicating a viable alternative without narcotic licensing.

Effect of Three Types of Mixed Anesthetic Agents Alternate to Ketamine in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Three Types of Mixed Anesthetic Agents Alternate to Ketamine in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider