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November 17, 2009Molecular CancerOpen Access

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

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Authors

CKCorina KohlerThe Francis Crick Institute RRRamin RadpourUniversity of Bern ZBZeinab BarekatiRoche (Switzerland)

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Implication

Biomarker evaluation reveals circulating cell-free nuclear DNA outperforms mitochondrial DNA in breast tumor detection, indicating greater diagnostic sensitivity and specificity.

Key Points

To evaluate the clinical potential of plasma circulating cell-free nuclear and mitochondrial DNA as diagnostic biomarkers in breast tumor management.
Assessed levels of plasma circulating cell-free nuclear DNA (ccf nDNA) and mitochondrial DNA (ccf mtDNA) in patients with breast tumors.
Evaluated and compared the diagnostic sensitivity and specificity of both circulating cell-free DNA types.
Both circulating cell-free nuclear and mitochondrial DNA demonstrate measurable potential as circulating biomarkers for breast tumor management.
Circulating cell-free nuclear DNA exhibits superior diagnostic utility compared to mitochondrial DNA, yielding higher sensitivity and specificity.

Cite This Study

Kohler et al. (2009) studied this question.

synapsesocial.com/papers/69d77093db9d5e1bf4b8a897 https://doi.org/10.1186/1476-4598-8-105

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Implication

Biomarker evaluation reveals circulating cell-free nuclear DNA outperforms mitochondrial DNA in breast tumor detection, indicating greater diagnostic sensitivity and specificity.

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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