Do early dual antiplatelet therapy, thrombolysis, and mechanical thrombectomy improve outcomes in patients with TIA and acute ischemic stroke?
Early initiation of dual antiplatelet therapy for TIA/minor stroke and timely reperfusion therapies for disabling acute ischemic stroke are critical for improving patient outcomes.
Dual antiplatelet therapy initiated within 24 hours of symptom onset and continued for 3 weeks reduces stroke risk in select patients with high-risk TIA and minor stroke. For select patients with disabling AIS, thrombolysis within 4.5 hours and mechanical thrombectomy within 24 hours after symptom onset improves functional outcomes.
Mendelson et al. (2021) studied this question.