Mechanisms of Neurodegenerative Disorders

Despite a vast array of causes of neurodegenerative diseases, research has identified common pathways through which the neurodegeneration proceeds. Part 1 of this neurological review article will address a confluence of research suggesting that neurodegeneration is often linked with the accumulation of insoluble protein aggregates; part 2, the mechanisms through which neurodegeneration occurs-apoptosis, necrosis, and excitotoxicity. Along with the common mechanisms for inducing neurodegeneration, we will also review common defense mechanisms that protect against toxic insults. Each of these pathways offers potential targets for pharmaceutical intervention.