Why the study?
Does aspirin improve clinical effectiveness and safety compared to other anticoagulants for VTE prophylaxis in patients after total hip and knee replacement?
Does aspirin improve clinical effectiveness and safety compared to other anticoagulants for VTE prophylaxis in patients after total hip and knee replacement?
Aspirin appears to have comparable clinical effectiveness and safety to other anticoagulants for VTE prophylaxis following total hip and knee replacement.
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Aspirin provides comparable VTE prophylaxis effectiveness and safety to anticoagulants after THR/TKR; supports its use as a lower-cost alternative in practice.
In terms of clinical effectiveness and safety profile, aspirin did not differ statistically significantly from other anticoagulants used for VTE prophylaxis after THR and TKR. Future trials should focus on noninferiority analysis of aspirin compared with alternative anticoagulants and cost-effectiveness.
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Matharu et al. (2020) studied this question.
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