What question did this study set out to answer?

To determine whether dietary supplementation with choline or its gut microbiota–dependent metabolite, TMAO, worsens pressure overload–induced heart failure.

December 24, 2015Circulation Heart FailureOpen Access

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

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To determine whether dietary supplementation with choline or its gut microbiota–dependent metabolite, TMAO, worsens pressure overload–induced heart failure.
Mice subjected to pressure overload were maintained on diets supplemented with either choline or the gut microbe–derived metabolite trimethylamine N-oxide (TMAO).
Diets supplemented with either choline or TMAO significantly enhanced the severity of heart failure in mice.
Dietary choline and its microbial conversion into TMAO qualitatively elevated animal susceptibility to heart failure progression.

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Implication

Animal study demonstrates exacerbated heart failure severity in mice fed choline or TMAO, suggesting gut microbiota metabolic pathways elevate cardiac susceptibility.

Cite This Study

Organ et al. (2015) studied this question.

synapsesocial.com/papers/69d776ce9c65a8c80448f7bc https://doi.org/10.1161/circheartfailure.115.002314

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Implication

Animal study demonstrates exacerbated heart failure severity in mice fed choline or TMAO, suggesting gut microbiota metabolic pathways elevate cardiac susceptibility.

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

Key Points

Discussion

Implication

Cite This Study

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

Key Points

Discussion

Implication

Cite This Study

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